HoloPath
Intelligent Procedure Based On Digital Holographic Imaging For Colonic Polyps And Adenocarcinomas Grading
Project Details
Project code: PN-IV-P7-7 .1-PED-2024-0511
Project director: Dr. Violeta Călin
Project type: National
Founding from: Unitatea Executivă pentru Finanțarea Invățământului Superior, a Cercetării, Dezvoltării și Inovării (UEFISCDI)
Status: Ongoing
Starting date: 08.01.2025
Ending date: 31.12.2026
Consortium:
– Carol Davila University of Medicine and Pharmacy
– SC OPTOELECTRONICA 2001 SA
Project Scope
HoloPath is a research project dedicated to transforming pathology through digital holographic microscopy (DHM) and artificial intelligence.
Our goal is to create and validate an intelligent procedure for grading (IPG) unstained colonic tissue biopsies, providing a faster, more accurate, and chemical-free alternative to traditional pathology methods.
What We Do
Capture holographic images (HIs) of unstained tissue samples, revealing nanoscale changes in protein distribution.
Apply AI algorithms to detect, classify, and grade tissue abnormalities such as:
– Lowgrade and highgrade dysplastic polyps
– Well, moderately, and poorly differentiated adenocarcinoma
Generate holographic biomarkers (HBs) that correlate with conventional histology and fibrosis markers.
Expected Outcomes
Digital library of HIs of colon polyps and adenocarcinoma and computed HBs
Algorithms for identification and assessment of histology structures
Graphical user interface for a facile use of the algorithms, accessing the digital library in an integrated procedure, as a diagnostic assisted procedure for Pathology